She has no problem sharing her thoughts on Twitter, but Kylie Jenner may have stepped over the line with her recent comments about a specific mental illness.
On Wednesday (November 6), the "Keeping Up with the Kardashians" star posted an old pic donning her darker locks and added the caption, "I miss my black hair I'm so bipolar :(."
Unfortunately, the politically incorrect comment didn't sit too well with other Twitter users. One observer fired back with, "Kylie Jenner just tweeted 'I miss my black I'm so Bipolar :(' . No, you're not 'so Bipolar', you're indecisive... and a moron."
Another wrote, "That was 100% the dumbest and most ignorant use of the word bipolar."
Miss Jenner has yet to respond to the negative tweets at this time.
Unique change in protein structure guides production of RNA from DNA
PUBLIC RELEASE DATE:
7-Nov-2013
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Contact: Anne Holden anne.holden@gladstone.ucsf.edu 415-734-2534 Gladstone Institutes
Gladstone-led study sheds light on critical molecular process
SAN FRANCISCO, CANovember 7, 2013One of biology's most fundamental processes is something called transcription. It is just one step of many required to build proteinsand without it life would not exist. However, many aspects of transcription remain shrouded in mystery. But now, scientists at the Gladstone Institutes are shedding light on key aspects of transcription, and in so doing are coming even closer to understanding the importance of this process in the growth and development of cellsas well as what happens when this process goes awry.
In the latest issue of Molecular Cell, researchers in the laboratory of Gladstone Investigator Melanie Ott, MD, PhD, describe the intriguing behavior of a protein called RNA polymerase II (RNAPII). The RNAPII protein is an enzyme, a catalyst that guides the transcription process by copying DNA into RNA, which forms a disposable blueprint for making proteins. Scientists have long known that RNAPII appears to stall or "pause" at specific genes early in transcription. But they were not sure as why.
"This so-called 'polymerase pausing' occurs when RNAPII literally stops soon after beginning transcription for a short period before starting up again," explained Dr. Ott, who is also a professor of medicine at the University of California, San Francisco, with which Gladstone is affiliated. "All we knew was that this behavior was important for the precise transcription of DNA into RNA, so we set out to understand how, when andmost importantlywhy."
The research team focused their efforts on a segment of RNAPII called the C-terminal domain, or CTD. This section is most intimately involved with transcription regulation. Previous research had found that CTD's chemical structure is modified before and during transcription. However, the combinations of modifications as well as precisely how they influence or control transcription remained unclear. So in laboratory experiments on cells extracted from mammals, the researchers took a closer look.
The first breakthrough came when the research team identified a new type of modification, known as acetylation, which regulated transcription.
"Our next breakthrough occurred when we pinpointed the precise locations on the CTD where acetylation occurredand realized it was unique to higher eukaryotes," explained Sebastian Schrder, PhD, the paper's first author. "We then wanted to see how this mammalian-specific acetylation fit into the realm of polymerase pausing."
Now that the team knew where the CTD became acetylated, their next goal was to find out when. Clues to the timing of acetylation came in experiments where they mutated RNAPII so that CDT was unable to become acetylated. In these cases, the length of polymerase pausing dropped, and the necessary steps for the completion of transcription failed to occur. Additional experiments revealed the elusive timeline of acetylation and transcription.
"RNAPII binds to DNA to prepare for transcription. Shortly after that we see polymerase pausingat which point the CTD becomes highly acetylated," continued Dr. Shrder. "Soon after the pause, CTD is then deacetylatedthe original modification is reversedand transcription continues without a hitch."
Polymerase pausing is not unique to mammalsin fact it was characterized in HIV, the virus that causes AIDS, many years agobut the fact that the CTD becomes acetylated just before or during the time when transcription is paused appears to be unique. Drs. Ott and Schrder argue that CTD acetylation is a stabilizer, preparing RNAPII for efficient completion of transcription and slowing down the process to make sure everything is functioning correctlynot unlike the final 'systems check' a pilot must perform before takeoff.
These findings offer important insight into the relationship between acetylation and transcription. And given the importance of transcription in the growth and maturation of cells in general, the team's result stands to inform scientists about a variety of cellular processes. These include, for example, the mechanisms behind stem-cell development and what happens when normal cellular growth spirals out of control, such as in cancer.
"However, there is still much we don't know about acetylation as it relates to transcription," said Dr. Ott. "For example, if CTD acetylation is important for stabilizing transcriptional pausing, why do we also see CTD acetylation at non-paused genes, although at different locations? Further, we believe there may be other steps in the transcription cycle that depend upon acetylation. Our most immediate goal is to find them. By doing so, we hope to deepen our understanding of one of nature's most elegant biological processes."
###
Dr. Schrder performed this research at Gladstone while completing his PhD at the University of Heidelberg, Germany. Eva Herker, PhD, Sean Thomas, Phd, Katrin Kaehlcke, Sungyoo Cho, Katherine Pollard, PhD, John Capra, PhD and Benoit Bruneau, PhD, also participated in this research at Gladstone, which was supported by the National Institutes of Health, the National Institute of Environmental Health Sciences, the Boehringer Ingelheim Fonds, the Human Frontiers Science Program and an E.G.G. fellowship.
About the Gladstone Institutes
Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and innovation to prevent, treat and cure cardiovascular, viral and neurological diseases. Gladstone is affiliated with the University of California, San Francisco.
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Unique change in protein structure guides production of RNA from DNA
PUBLIC RELEASE DATE:
7-Nov-2013
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Contact: Anne Holden anne.holden@gladstone.ucsf.edu 415-734-2534 Gladstone Institutes
Gladstone-led study sheds light on critical molecular process
SAN FRANCISCO, CANovember 7, 2013One of biology's most fundamental processes is something called transcription. It is just one step of many required to build proteinsand without it life would not exist. However, many aspects of transcription remain shrouded in mystery. But now, scientists at the Gladstone Institutes are shedding light on key aspects of transcription, and in so doing are coming even closer to understanding the importance of this process in the growth and development of cellsas well as what happens when this process goes awry.
In the latest issue of Molecular Cell, researchers in the laboratory of Gladstone Investigator Melanie Ott, MD, PhD, describe the intriguing behavior of a protein called RNA polymerase II (RNAPII). The RNAPII protein is an enzyme, a catalyst that guides the transcription process by copying DNA into RNA, which forms a disposable blueprint for making proteins. Scientists have long known that RNAPII appears to stall or "pause" at specific genes early in transcription. But they were not sure as why.
"This so-called 'polymerase pausing' occurs when RNAPII literally stops soon after beginning transcription for a short period before starting up again," explained Dr. Ott, who is also a professor of medicine at the University of California, San Francisco, with which Gladstone is affiliated. "All we knew was that this behavior was important for the precise transcription of DNA into RNA, so we set out to understand how, when andmost importantlywhy."
The research team focused their efforts on a segment of RNAPII called the C-terminal domain, or CTD. This section is most intimately involved with transcription regulation. Previous research had found that CTD's chemical structure is modified before and during transcription. However, the combinations of modifications as well as precisely how they influence or control transcription remained unclear. So in laboratory experiments on cells extracted from mammals, the researchers took a closer look.
The first breakthrough came when the research team identified a new type of modification, known as acetylation, which regulated transcription.
"Our next breakthrough occurred when we pinpointed the precise locations on the CTD where acetylation occurredand realized it was unique to higher eukaryotes," explained Sebastian Schrder, PhD, the paper's first author. "We then wanted to see how this mammalian-specific acetylation fit into the realm of polymerase pausing."
Now that the team knew where the CTD became acetylated, their next goal was to find out when. Clues to the timing of acetylation came in experiments where they mutated RNAPII so that CDT was unable to become acetylated. In these cases, the length of polymerase pausing dropped, and the necessary steps for the completion of transcription failed to occur. Additional experiments revealed the elusive timeline of acetylation and transcription.
"RNAPII binds to DNA to prepare for transcription. Shortly after that we see polymerase pausingat which point the CTD becomes highly acetylated," continued Dr. Shrder. "Soon after the pause, CTD is then deacetylatedthe original modification is reversedand transcription continues without a hitch."
Polymerase pausing is not unique to mammalsin fact it was characterized in HIV, the virus that causes AIDS, many years agobut the fact that the CTD becomes acetylated just before or during the time when transcription is paused appears to be unique. Drs. Ott and Schrder argue that CTD acetylation is a stabilizer, preparing RNAPII for efficient completion of transcription and slowing down the process to make sure everything is functioning correctlynot unlike the final 'systems check' a pilot must perform before takeoff.
These findings offer important insight into the relationship between acetylation and transcription. And given the importance of transcription in the growth and maturation of cells in general, the team's result stands to inform scientists about a variety of cellular processes. These include, for example, the mechanisms behind stem-cell development and what happens when normal cellular growth spirals out of control, such as in cancer.
"However, there is still much we don't know about acetylation as it relates to transcription," said Dr. Ott. "For example, if CTD acetylation is important for stabilizing transcriptional pausing, why do we also see CTD acetylation at non-paused genes, although at different locations? Further, we believe there may be other steps in the transcription cycle that depend upon acetylation. Our most immediate goal is to find them. By doing so, we hope to deepen our understanding of one of nature's most elegant biological processes."
###
Dr. Schrder performed this research at Gladstone while completing his PhD at the University of Heidelberg, Germany. Eva Herker, PhD, Sean Thomas, Phd, Katrin Kaehlcke, Sungyoo Cho, Katherine Pollard, PhD, John Capra, PhD and Benoit Bruneau, PhD, also participated in this research at Gladstone, which was supported by the National Institutes of Health, the National Institute of Environmental Health Sciences, the Boehringer Ingelheim Fonds, the Human Frontiers Science Program and an E.G.G. fellowship.
About the Gladstone Institutes
Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and innovation to prevent, treat and cure cardiovascular, viral and neurological diseases. Gladstone is affiliated with the University of California, San Francisco.
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Roughly three-quarters of South Africa's Jewish population are descendants of Lithuanian immigrants. Of these peasants, townspeople, tradesmen, shopkeepers and intellectuals who fled centuries of persecution and embarked on a passage to Africa, many dreamed of a new land and the promise of new beginnings. Kenneth Bonert's ancestors were part of this diaspora. In his debut novel, written in language as dense and varied as the South African landscape he describes, Bonert delivers a taut, visceral account of a young Jewish boy's African life.
These are the years of the Great Depression, the period between the wars. The protagonist, Isaac Helger, arrives in South Africa with his mother and younger sister, reuniting with a father who had made the journey years before. Their reunion marks the beginning of family life, but the fate of the relatives left behind, and the impact of a separation they all pray will be temporary, will reach far into their future. Most affected by this separation is Gitelle, Isaac's mother — a woman who has more reason than most to leave the past behind.
The voices of Isaac and his mother especially are brought to life through Bonert's skilful prose — a beguiling mixture of delicate, poetic sensitivity and rugged, at times despondent, masculinity. Dialogue is believably rendered in language that is visceral and heavily inflected with the Yiddish, Afrikaans and South African accent that make up the particular voice of the Helger family's migration. As their ship lands in Cape Town, Gitelle's first experience of this new country is almost overwhelming, so vivid is the description:
Colors burned the air, blood flowers, thorny eruptions of vermilion, limeyellow smears on the rocks like veins of fresh paint ... she saw human beings burned the color of coal or dark-brewed tea or cured leather; she smelled their alien sweat and their tangy cooking, heard the mad bibbering of their manifold tongues. A strange music that made her heart sing in fear of this shattering place.
Gitelle does not linger long on this fear, for we soon learn that what she has survived is so terrible that there is little left that she cannot endure. When we meet Gitelle, her face is covered with a veil, and while the source and nature of the deformity she is hiding are not clear in the early pages of the book, her determination is. Very quickly she sets to building a home for her family. In one memorable scene she clears out the "bladerfools" and "parasites" — the friends she feels are sapping her watchmaker husband's time and energy.
Born in South Africa, grandson to Lithuanian immigrants, Kenneth Bonert has contributed stories to the magazines Grain and Fiddlehead. His novella, "Peacekeepers, 1995," appeared in McSweeney's.
Richard Dubois/Courtesy of Houghton Mifflin Harcourt
Born in South Africa, grandson to Lithuanian immigrants, Kenneth Bonert has contributed stories to the magazines Grain and Fiddlehead. His novella, "Peacekeepers, 1995," appeared in McSweeney's.
Richard Dubois/Courtesy of Houghton Mifflin Harcourt
Though Gitelle remains a necessary and constant focus of the narrative, it is Isaac's life that the story follows. He is not always a sympathetic character — rough-hewn, bull-headed and often violent. As Isaac grows from a boyhood filled with fights, truancy and early disregard for the rules of this new place, his mother urges him constantly to a better future. Theirs is a potentially destructive relationship of tenderness and mutual dependence.
Together they dream of moving to a house in a better suburb — one that will have room for the sisters she still hopes, despite the passage of time and anti-Jewish immigration laws, to rescue from Lithuania. Spurred by her blind faith, Isaac leaves school with no qualifications and bets on several money-making schemes (some legal, many not). Eventually, in a show of youthful independence, he defies his mother's wishes and settles in as an apprentice in an auto-repair shop.
Throughout all this, Bonert does not shirk from the fetid truth upon which the opportunities of immigrants such as the Helger's are built. The Lion Seeker deftly handles the questions of compliance and collusion that mark this period in history. Fleeing hardship in Europe, Isaac and his family now claim a new status; no longer at the bottom of the pile. Life may be difficult and they may still face prejudice, but at least they are not black. Gitelle, with a determined sense of self-preservation, puts it to Isaac plainly: "We are Jews but we are Whites here. If People see you with Coloreds and hear you talk like that ... then they will think maybe we have coffee in our blood also ... That's dangerous. Do you understand me?"
Thankfully, Bonert is too thoughtful a writer to allow Isaac an epiphany and the resulting bleeding heart. Instead, Isaac is only too willing to claim the superior status that his white skin gives him. His prejudice is not a thought-out thing, although no less diminishing for that lack of intent. Bonert makes this point with carefully considered characterization and scenes that are unforgiving in their judgement. Isaac's easy acceptance of the privileges his color allows make him as complicit as all around him.
Isaac falls in love with the lithesome Yvonne, the spoiled only child of a wealthy English-speaking couple. She's of a class that is voluble in their liberal affectations. No matter that the very fabric of their lives depends on the inequalities of this pre-apartheid era. Yvonne's criticism that Isaac is willfully ignorant of the "Native Question" causes tension, causing Isaac is at last to question his easy acceptance of the status quo. However, his own experience of working with blacks — and forming friendships, of a kind, with them — far outstrips the tennis-club rhetoric of Yvonne and her kind.
All through this growing up, and the richly-drawn glimpses we have of South Africa and the wider world, there is an assured confidence to Bonert's narration, with an undercurrent of menace that is skilfully and affectingly wrought. Isaac settles uneasily into manhood with the possibility of war in Europe looming ever larger, as well as the quotidian brutality of the color-bar and the constant reminders of the precarious nature of life as a Jew. Gitelle still mourns the family she has left behind, never giving up her determination to bring them to safety. When, at great personal cost to herself and the possible exposure of a closely held secret, it seems she has found a way, Isaac makes a catastrophic decision for which one does not imagine there can be redemption.
This is a first novel, and so it is easy to forgive the occasional tremors in plotting that felt, towards the end of the book, too close to melodrama, and the inclusion of an epilogue that is out of voice and feels tacked on for poignant effect. The Lion Seeker is a captivating story, offering at times page-turning thrills and at others a painful meditation on destiny and volition. All too often debut novels stay too close to a writer's own life; it is a great gift to be able to mine family history and flex the imagination to create something that exudes such urgency and brilliance as this memorable book.
Amid the clamor of "bring your own device" (BYOD), a question lurks in the background: "What happens to technical service and support?" Concerns for the tech support function encompass the extremes, from agents being overwhelmed with calls, to their becoming inhabitants of a help desk ghost town.
On the one hand, it’s easy to imagine a flood of calls as employees attempt to access wireless networks or synch their e-mail, especially in companies that permit the use of any device type. At the same time, as more people own smartphones, they are increasingly accustomed to resolving issues independently, through online forums, communities and other means of self-support.
By 2016, says Gartner analyst Jarod Greene, help desks will see a 25% to 30% drop in user-initiated call volume, as BYOD drives a companion trend of BYOS, or “bring your own support.”
Iranian Foreign Minister Mohammed Javad Zarif waits for the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
Iranian Foreign Minister Mohammed Javad Zarif waits for the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
U.S. Under Secretary of State for Political Affairs Wendy Sherman arrives prior to the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
A general view shows participants before the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
EU High Representative for Foreign Affairs Catherine Ashton, left, speaks with Iranian Foreign Minister Mohammed Javad Zarif, right, during a photo opportunity prior the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
EU High Representative for Foreign Affairs Catherine Ashton, right, walks next to Iranian Foreign Minister Mohammed Javad Zarif, left, during a photo opportunity prior to the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
GENEVA (AP) — Iran's chief nuclear negotiator signaled progress at talks with six world powers Thursday on a deal to cap some of his country's atomic programs in exchange for limited relief from sanctions stifling Iran's economy, saying the six had accepted Tehran's proposals on how to proceed.
U.S. officials said Secretary of State John Kerry will fly to Geneva on Friday to participate in the negotiations — a last-minute decision that suggests a deal could be imminent.
A senior State Department official traveling with Kerry in Amman, Jordan, said the secretary would come to Geneva "to help narrow differences in negotiations." The official spoke on condition of anonymity because he was not authorized to release information about the Geneva visit.
Even if an agreement is reached, it would only be the start of a long process to reduce Iran's potential nuclear threat, with no guarantee of ultimate success.
Still, a limited accord would mark a breakthrough after nearly a decade of mostly inconclusive talks focused on limiting, if not eliminating, Iranian atomic programs that could be turned from producing energy into making weapons.
Tehran's chief nuclear negotiator, Abbas Araghchi, told Iranian state TV that the six — the United States, Russia, China, Britain, France and Germany — "clearly said that they accept the proposed framework by Iran." He later told CNN that he thinks negotiators at the table are now "ready to start drafting" an accord that outlines specific steps to be taken.
Though Araghchi described the negotiations as "very difficult," he told Iranian state TV that he expected agreement on details by Friday, the last scheduled round of the current talks.
The upbeat comments suggested that negotiators in Geneva were moving from broad discussions over a nuclear deal to details meant to limit Tehran's ability to make atomic weapons. In return, Iran would start getting relief from sanctions that have hit its economy hard.
U.S. officials said Kerry will travel to the Geneva talks after a brief stop in Israel, where he will hold a third meeting with Israeli Prime Minister Benjamin Netanyahu, who has spoken out against any limited deal that would allow the Iranians sanctions relief.
In Geneva, Kerry is expected to meet Friday with the European Union's top diplomat, Catherine Ashton, and Iranian Foreign Minister Mohammad Javad Zarif, the officials said. They spoke on condition of anonymity because they were not authorized to comment on the schedule.
The talks are primarily focused on the size and output of Iran's enrichment program, which can create both reactor fuel and weapons-grade material suitable for a nuclear bomb. Iran insists it is pursuing only nuclear energy, medical treatments and research, but the United States and its allies fear that Iran could turn this material into the fissile core of nuclear warheads.
International negotiators representing the six powers declined to comment on Araghchi's statement. Bur White House spokesman Jay Carney elaborated on what the U.S. calls a "first step" of a strategy meant to ultimately contain Iran's ability to use its nuclear program to make weapons.
An initial agreement would "address Iran's most advanced nuclear activities; increase transparency so Iran will not be able to use the cover of talks to advance its program; and create time and space as we negotiate a comprehensive agreement," Carney told reporters in Washington.
The six would consider "limited, targeted and reversible relief that does not affect our core sanctions," he said, alluding to penalties crippling Tehran's oil exports. If Iran reneges, said Carney, "the temporary, modest relief would be terminated, and we would be in a position to ratchet up the pressure even further by adding new sanctions."
He described any temporary, initial relief of sanctions as likely "more financial rather than technical." Diplomats have previously said initial sanction rollbacks could free Iranian funds in overseas accounts and allow trade in gold and petrochemicals.
Warily watching from the sidelines, Israel warned against a partial agreement that foresees lifting sanctions now instead of waiting for a rigorous final accord that eliminates any possibility of Iran making nuclear weapons.
At a meeting with U.S. legislators in Jerusalem, Netanyahu spoke of "the deal of the century for Iran." While divulging no details, he said the proposed first step at Geneva "will relieve all the (sanctions) pressure inside Iran."
The last round of talks three weeks ago reached agreement on a framework of possible discussion points, and the two sides kicked off Thursday's round focused on getting to that first step.
Thursday's meeting ended about an hour after it began, followed by bilateral meetings, including one between the U.S and Iranian delegations. EU spokesman Michael Mann said the talks were "making progress."
Before the morning round, Zarif, the Iranian foreign minister, met with the EU's Ashton, who is convening the meeting. Asked afterward about the chances of agreement on initial steps this week, Zarif told reporters: "If everyone tries their best, we may have one."
After nearly a decade of deadlock, Iran seems more amenable to making concessions to the six countries. Iran's new president, Hassan Rouhani, has indicated he could cut back on the nuclear program in exchange for an easing of sanctions.
Despite the seemingly calmer political backdrop, issues remain.
Iranian hardliners want a meaningful — and quick — reduction of the sanctions in exchange for any concessions, while some U.S. lawmakers want significant rollbacks in Iran's nuclear activities in exchange for any loosening of actions.
_____
Associated Press Diplomatic Writer Matthew Lee in Amman, Jordan, contributed to this report. AP writers Josef Federman in Jerusalem, Jim Kuhnhenn in Washington and Nasser Karimi in Tehran also contributed.
Feeling perky post-split? Liberty Ross proudly flaunted her body on the red carpet of the MOCA Awards in Beverly Hills on Wednesday, Nov. 6. The 35-year-old estranged wife of Rupert Sanders went braless in a see-through black dress that exposed her nipples.
Ross appeared to be in great spirits at the event, flashing a big smile to photographers while posing on the carpet. The model styled a short, sleeveless dress with a sheer black bodice and white-and-black printed skirt and black high-heels. The British mom of two also playfully posed in a pair of dark shades, which she later placed on the top of her head.
Ross recently opened up to Vanity Fair about life after her husband's public affair. The Snow White and the Huntsman director was caught cheating with the star of his movie, Kristen Stewart, on July 17, 2012.
"It was horrible," Ross told the December issue of the magazine. "It was really the worst, really the worst."
After filing for divorce from Sanders in January 2013, Ross, who is now dating music honcho Jimmy Iovine, said she's finally moving on. "I have no words to describe what we went through," she told Vanity Fair. "But I think, for me, something always has to completely die for there to be a rebirth. And, for me, I feel like I'm going through a rebirth."
Out for a quick trim in Beverly Hills, CA today (November 7), "Mad Men" momma January Jones took her son Xander to get a haircut.
The 35-year-old dressed casually, wearing shades, and sporting a white button down and blue jeans. Little Xander rode along on his mommy's hip, wearing a gray cap, blue polo and jeans.
In related news, AMC announced that "Mad Men's" seventh and final season will be 14 episodes long and be split into two hlaves, with the first seven episodes of the extended season airing in Spring 2014 and the second seven episodes airing in Spring 2015.
Fans of the show can now purchase the series' sixth season on DVD, which just hit stores this week. Enjoy!
The sad march towards tribal fiefdoms continued Thursday, as Google announced that it will only allow Chrome for Windows users to download extensions hosted by Google’s own Chrome Web Store starting in January.
Google says the decision to transform Chrome into a gated community stems from security concerns, in an echo of the official reason that Microsoft moved to the Windows Store model to distribute modern UI apps. Google engineering director Erik Kay points the finger at the damage caused by rogue extensions in a blog post detailing the lock-down.
“Bad actors have abused this mechanism, bypassing the prompt to silently install malicious extensions that override browser settings and alter the user experience in undesired ways, such as replacing the New Tab Page without approval. In fact, this is a leading cause of complaints from our Windows users.”
The policy shift will no doubt make it easier for Google to police the sanctity of said extensions. Google’s been on a bit of a security tear recently; last week, the company announced plans to step up Chrome’s malware-busting chops.
But, it’s also worth noting, developers who want to include their Chrome Web Store have to pay a $5 registration fee—and if your Chrome Web Store-hosted app or extension generates income, Google will take a 5 percent cut of the revenue.
Everyday Chrome users would not have the same ability under the new extension policy, though developers and enterprise Chrome users will still be able to install “unauthorized” extensions.
Crappy par for a crappy course
Sadly, the shift away from the Open Web ideal is nothing new.
“And I think that we’ve really invested a lot into the open standards behind all that. And I’ve personally been quite saddened at the industry’s behavior around all these things… I’d like to see more open standards, more people getting behind things, that just work, and more companies involved in those ecosystems.”
Lofty ideals indeed, and noble ones. Just don’t forget to practice what you’re preaching, Google.
His split from Miranda Kerr went viral a few weeks ago, and Orlando Bloom is ready to open up about the finale of his three-year marriage.
During an interview with CBS "Sunday Morning," the 36-year-old actor revealed the real reasons behind the couple's decision to part ways.
"You know, when you have two people who are incredibly busy and who are both very visible in the world, I think it can be challenging to keep that, that schedule and that kind of life in the same track, you know," Bloom explained.
He added, "It's very challenging. You know, I love Miranda and she loves me. We both adore and love our son. We both recognize and realize that we're going to be in each other's lives for the rest of our lives, raising our son.”
In October, the couple went public with the news of the breakup via their rep, who stated, “In a joint statement, Orlando Bloom and Miranda Kerr have announced that they have been amicably separated for the past few months. After six years together, they have recently decided to formalize their separation."
Regardless of whether you saw them as a menace, the first 3D-printed guns were an objectively far, boxy cry from the weapons we're used to seeing. But just from looking at Solid Concept's newest firearm offering, you'd have no idea that it, too, started out as a mere 3D CAD file before being printed to life.
This combination of Sept. 10 and 23, 2013 photos provided by NASA shows six comet-like tails radiating from a body in the asteroid belt, designated P/2013 P5. The Hubble Space Telescope discovered it in the asteroid belt between the orbits of Mars and Jupiter. A research team led by the University of California at Los Angeles believes the asteroid is rotating so much that its surface is flying apart. It’s believed to be a fragment of a larger asteroid damaged in a collision 200 million years ago. (AP Photo/NASA, ESA, D. Jewitt - UCLA)
This combination of Sept. 10 and 23, 2013 photos provided by NASA shows six comet-like tails radiating from a body in the asteroid belt, designated P/2013 P5. The Hubble Space Telescope discovered it in the asteroid belt between the orbits of Mars and Jupiter. A research team led by the University of California at Los Angeles believes the asteroid is rotating so much that its surface is flying apart. It’s believed to be a fragment of a larger asteroid damaged in a collision 200 million years ago. (AP Photo/NASA, ESA, D. Jewitt - UCLA)
CAPE CANAVERAL, Fla. (AP) — This is one strange asteroid.
The Hubble Space Telescope has discovered a six-tailed asteroid in the asteroid belt between the orbits of Mars and Jupiter. Scientists say they've never seen anything like it. Incredibly, the comet-like tails change shape as the asteroid sheds dust. The streams have occurred over several months.
A research team led by the University of California, Los Angeles, believes the asteroid, designated P/2013 P5, is rotating so much that its surface is flying apart. It's believed to be a fragment of a larger asteroid damaged in a collision 200 million years ago.
Scientists using the Pan-STARRS telescope in Hawaii spotted the asteroid in August. Hubble picked out all the tails in September.
The discovery is described in this week's issue of Astrophysical Journal Letters.
TORONTO (AP) — A new video that surfaced Thursday showed Toronto Mayor Rob Ford threatening to "murder" someone and "poke his eyes out" in a rambling rage, deepening the conviction among both critics and allies that he is no longer fit to lead North America's fourth largest city.
The mayor told reporters moments after the video was posted online that he was "extremely, extremely inebriated" in it and "embarrassed" by it. The context of the video is unknown and it's unclear who the target of Ford's wrath is. The video, which appeared at length on the Toronto Star's website and in clips on the Toronto Sun's website, prompted round of calls for Ford to step down.
The controversy surrounding Ford escalated last week when police announced they had obtained a different, long-sought video that shows Ford smoking a crack pipe. After months of evading the question, Ford admitted Tuesday to smoking crack in a "drunken stupor" about a year ago.
Despite immense pressure, the mayor has refused to resign or take a leave of absence.
Ford, who is married with two school age children, said Thursday he made mistakes and "all I can do is reassure the people. I don't know what to say."
"It's extremely embarrassing. The whole world is going to see it," said Ford, who is 44.
City councilors stepped up efforts to force Ford out of office, although there is no clear legal path for doing so.
In the blurry and shaky new video, Ford paces around, frantically waves his arms and rolls up his sleeves as he says he'll "make sure" the unknown person is dead.
Ford tells another person in the room, possibly the man filming the video, that he wants to "kill" someone. "Cause I'm going to kill that (expletive) guy," Ford says. "No holds barred brother. He dies or I die."
At one point he says "My brothers are, don't tell me we're liars, thieves, birds" and then later refers to "80-year-old birds."
The Toronto Star said that it purchased the video for $5,000 from "a source who filmed it from someone else's computer" and the paper said it was told "the person with the computer was there in the room."
City Councilor James Pasternak urged Ford to make a "dignified exit."
"The video is very disturbing," he said. "It's very upsetting, it's very sad."
Ford lawyer Dennis Morris told The Associated Press the context of the video "is skeletal." ''Was it taken eight, 10 months ago or a short time ago?" he said.
Earlier Thursday, Morris said he was in talks with the police for Ford to view the video that appears show the mayor smoking crack. Morris said Ford would not answer questions.
Police obtained that video in the course of a drug investigation into the mayor's friend and occasional driver. They have not charged Ford, saying the video doesn't provide enough evidence against him.
Ford, who grew up in a wealthy and politically influential family, was elected to City Hall three years ago on a wave of conservative backlash in Toronto's outer suburbs against perceived wasteful spending.
But city councilors say they have been mostly working around Ford since he took office. The mayor's power is more limited in Toronto, a city of 2.7 million people, than in many large U.S. cities; he has just one vote on a council of 44 members.
Municipal law makes no provision for the mayor's forced removal from office unless he's convicted and jailed for a criminal offence.
City Councilor Denzil Minnan-Wong, a member of Ford's executive committee, said Thursday he plans to amend a motion he has filed that would ask Ford to take a leave of absence. The amendment, which could be voted on next Wednesday, takes the unprecedented step of asking the province of Ontario to pass legislation to remove the mayor if he does not agree to take a leave of absence.
The province, however, has no plans to step in and amend the law to allow Ford to be forced from office, Ontario Municipal Affairs Minister Linda Jeffrey reaffirmed Thursday.
City Councilor Giorgio Mammoliti, a Ford ally, urged the mayor to enter rehab and said in a statement he fears "that if the mayor does not get help now he will succumb to health issues related to addiction."
Ford acknowledged a drinking problem for the first time Sunday and apologized.
In a television interview, Ford's mother and sister acknowledged he had problems but insisted he was not an addict of any sort and defended his ability to continue on as mayor.
His mother, Diane, said she told her son during a family meeting last week to get a driver, lose weight, get an alcohol detector in his car and watch the company he keeps. But she insisted he did not need to enter rehab.
"I didn't say shape up or ship out, but I did say, 'Rob, you maybe got to smarten up a little bit," Diane told CP24 television. "He's got a huge weight problem and he knows that and I think that' is the first thing he needs to attack."
"If he was really, really in dire straits and really needed help I'd be the first one ... I'd put him in my care and take him there," she said.
His sister Kathy added, "Robbie is not a drug addict. I know because I'm a former addict."
The allegations about Ford smoking crack first emerged earlier this year when reporters from the Toronto Star and the U.S. website Gawker separately said they saw that video, but they did not obtain a copy.
Police said they are prohibited releasing it because is evidence before the courts.
Toronto Police Chief Bill Blair has said police have a second tape, but he has declined to discuss what's on it. Police spokesman Mark Pugash told the AP the video released Thursday is not the tape Blair talked about.
___
Follow Rob Gillies on Twitter at —http://twitter.com/rgilliescanada
The global market for PaaS (platform as a service) is set to leap from $3.8 billion last year to more than $14 billion in 2017 as companies look to cut infrastructure costs and speed up application development, according to newly released research from analyst firm IDC.
Overall, the compound annual growth rate for PaaS during this period will be roughly 30 percent, compared to the 4 percent growth rate this year for IT spending overall, according to IDC.
The expected rise in PaaS spending is due to "indications of faster acceptance of the competitive PaaS buying proposition and new information concerning past years, particularly related to the acceptance of and market penetration of Microsoft Azure," the report states.
Various segments of the market
IDC breaks PaaS into a number of sub-segments, including APaaS (application platform as a service), DPaaS (database platform as a service), cloud-based test and IPaaS (integration platform as a service).
There's also been an emergence of PaaS providers focusing on specific industries, but these companies are "hedging their risks" by linking up with generalized PaaS players such as Salesforce.com, Microsoft and IBM, IDC said. "By doing so, they don't have to reinvent the most common platform services and can focus on developing their own value-add," the report states.
In general, companies are flocking to public PaaS because doing so can lower IT infrastructure spending while providing high availability and scale, IDC said.
It's also possible to create applications more quickly because PaaS makes it easier to perform functional and load testing, as well as to deploy software, according to the report.
This in turn is creating a murky picture of sorts for programmers. "One of the biggest unknowns related to public PaaS is its potential impact on IT staff," the report states. "Because public PaaS improves developer productivity by a factor of two or more, what happens to the developer workforce? Do enterprises make more use of IT or elect to take some or all of the benefit in terms of reducing the developer workforce? The answer lies somewhere in the middle."
On a geographic basis, 65.2 percent of PaaS revenue was derived from the Americas in 2012, and that's not expected to change much by 2017, dropping only to 62.3 percent. This is because many of the initial PaaS startups have their roots in the Americas, resulting in a "revenue bias," IDC said.
But PaaS revenue growth in Asia-Pacific including Japan "continues to boom," with 14.1 percent market share in 2012 and an expected 19.0 percent in 2017.
Europe, the Middle East and Africa accounted for 20.7 percent of PaaS revenue in 2012, but that total is expected to drop slightly, to 18.7 percent, by 2017.
Chris Kanaracus, IDG News Service , IDG News Service
Chris Kanaracus covers enterprise software and general technology breaking news for the IDG News Service. More by Chris Kanaracus, IDG News Service
After offering birthday wishes to friend Brittny Gastineau, Kim Kardashian inadvertently raised suspicions that she is linked to the Illuminati, a conspiratorial group that theorists believe controls the world.
On Wednesday (November 7), the "Keeping up with the Kardashians" starlet posted an Instagram message to Brittny that read, “Happy Birthday to my best friend @brittgastineau We’ve shared soooo many memories over the past years! I love you! #RideorDie.” However the confusion surrounds the nature of the photo attached to the post. The snapshot features a collage of the two besties, except it showcases them within the monogram of the iconic pyramid with an eye in the center.
After hearing the feedback from followers linking her to the group, the 33-year-old posted a response the following day, writing, "I posted a IG collage for my bff @BrittGastineau & people say its the illuminate!"
Clearly confused, Kim also wrote, "What is the illuminate? A religion?… I’m a Christian. A cult?… not into that sorry! It had an eye on it, which reminded me of Britt bc her company ‘eye on glam’ & reminds me of against evil eye bracelets we wear. So sorry guys it was just a cool design I saw on one of those IG collage apps.” See for yourself, and determine whether or not Kanye West's soon-to-be wife is controlling with world as a member of the Illuminati!
A moderate Republican group that is fed up with the recent onslaught of uncompromising GOP lawmakers and candidates is preparing a multimillion dollar campaign against hardline conservative forces during the 2014 midterm elections.
The Main Street Partnership, a center-right activist group led by Steve LaTourette, an Ohio Republican who left Congress earlier this year to join a lobbying firm, aims to spend as much as $8 million to defend sitting Republican lawmakers facing threats from conservative primary challengers.
Through a combination of direct mail, online ads and support for grassroots organizing, the Partnership plans to defend several moderate Republican incumbents next year. The group also plans to launch a direct strike on the Club for Growth, a free-market advocacy network that supports conservative challengers to incumbent GOP lawmakers.
“To this moment in time we’ve never really fought back, and it’s time to take our party back from these guys,” LaTourette, who left Congress earlier this year, told Yahoo News in an interview. “The center-right of the party has really been out-manned and out-maneuvered by the very conservative wing of the party when it comes to fundraising, when it comes to the ability to put boots on the ground and deliver a message in Republican primaries.”
To date, groups like the Club for Growth and the Senate Conservatives Fund have already formally endorsed a number of conservative challengers to sitting Republicans with records they deem as insufficiently conservative.
Some Republicans see these efforts as counterproductive because it forces the incumbents to devote resources to a primary fight that they could be spending on defeating Democrats in the general election.
They point to cases in the last two election cycles when tea party candidates defeated more centrist primary opponents only to go on to embarrassing defeats in the general election. The Partnership on Wednesday released a video that pointed to some of those failed candidates — particularly Christine “I am not a witch” O'Donnell in Delaware and Todd “legitimate rape” Akin in Missouri. (The Club for Growth did not endorse either of those candidates.)
LaTourette also said inaction in Congress had reached a point of frustration, particularly the failure of House Republicans to find a compromise deal to avoid the so-called “fiscal cliff” last year and the debate over the government shutdown and debt ceiling last month.
The Partnership also hopes it can ward off some of the new conservative challengers next year by targeting the groups that support them. To accomplish this, LaTourette intends to launch a website called “The Club for Democratic Growth” in an attempt to undermine the Club for Growth, he told Yahoo News.
“We are going to spend some time educating people as to exactly who they are, and who they are is a small collection of very, very wealthy people who have been able to gain a disproportionate voice in Republican politics,” LaTourette said. “We will be profiling one of their board members or champions on a regular basis with their own words. … We’re going to use their words against them.”
Going up against the Club would be a tall order for the Partnership. While LaTourette’s goal is to spend about $8 million for the campaign, the group has only raised about $2 million so far. In 2012, the group’s political action committee spent just $1.1 million.
When reached by phone Thursday, a spokesman for the Club said the group was not concerned about the Partnership’s plans for next year.
“We don’t really care what some lobbyist has to say about us,” Club spokesman Barney Keller told Yahoo News.
“What groups like this don’t understand is that all that matters to the voters are the candidates and the policies that the candidates support," Keller said. "If being a big government liberal was a ticket to winning a Republican primary then more big government liberals would win Republican primaries. All we do is provide candidates with the resources they need to get the message out and then the voters are the ones picking the candidates.”
The U.S. Congress should take action to slow a skyrocketing number of "deceptive" patent infringement demand letters sent from patent licensing firms to small businesses, witnesses told a Senate committee.
During the past 18 months, PAEs (patent assertion entities), those firms with patent licensing as their primary business model, have been flooding U.S. businesses with letters alleging patent infringement, threatening lawsuits and demanding settlements in the tens of thousands of dollars, witnesses told the consumer protection subcommittee of the U.S. Senate Commerce, Science, and Transportation Committee Thursday.
In many cases, the patent demand letters have accused recipients of infringing "every-day technology" such as online shopping carts and Wi-Fi routers, said Julie Samuels, a senior staff attorney at the Electric Frontier Foundation. "These letters really had nothing to do with patent law," she said. "They merely used the guise of patent law to conduct, frankly, run-of-the-mill extortion."
The PAE demand letters often don't identity the owner of the patent or the patent the letter recipient is alleged to have infringed, said Mark Chandler, general counsel at Cisco Systems. Some PAEs are "charlatans, dressed up as innovators," he said.
"This is all about fraud," said Jon Bruning, attorney general in Nebraska. "This is about extortion. This is about fear. For little companies ... it's their life or death. For some guy who invested his last $100,000, this letter will take him down."
Chandler called on Congress to take action to rein in PAEs, often called patent trolls. Congress should require PAEs that send more than 10 demand letters to submit those letters to a proposed online registry run by the U.S. Federal Trade Commission, and lawmakers should require PAEs to identity the alleged infringing technology in the letters, he said.
PAEs should also be required to disclose the names of the patent owners and to disclose all previous licensing agreements covering the patents, including any commitments to license the patents on fair and reasonable terms, he said.
No PAEs appeared at the hearing, but some committee Republicans and witness Adam Mossoff, an intellectual property professor at the George Mason University School of Law, questioned the need for changes in patent law. Complaints about PAE demand letters are "anecdotal," Mossoff said, and there's little evidence of major harms to innovation or to consumers.
Patent licensing is a legitimate business that's been around for over a century in a U.S. patent system that has helped create a huge innovation-based economy, Mossoff added. "Systemic changes to the patent system should not be based on rhetoric, anecdotes, invalid studies and incorrect claims about the historical and economic significance of patent licensing," he said. "If there ever was a case where caution was called for, this is it."
FILE - In this Feb. 10, 2013 file photo, Chris Brown arrives at the 55th annual Grammy Awards, in Los Angeles. Brown on Wednesday Nov. 6, 2013, countersued a man who claimed the R&B singer injured him during a fight outside a recording studio earlier this year. Brown's suit seeks unspecified damages and claims Sha'keir Duarte punched and kicked him during the fight. (Photo by Jordan Strauss/Invision/AP, File)
LOS ANGELES (AP) — Chris Brown has countersued a man who accused the R&B star's entourage of attacking him outside a recording studio earlier this year.
The singer filed an assault and battery lawsuit Wednesday against Sha'keir Duarte, who claimed in an earlier suit that he was injured when a fight erupted between Brown and Frank Ocean's entourages in January outside a West Hollywood studio.
Duarte sued Brown in August and accused the singer of being the aggressor in the fight. Brown's countersuit however accuses Duarte of instigating the fight by pushing, kicking and punching the R&B singer and threatening to kill him.
Brown, 24, is seeking unspecified damages.
Duarte's attorney Joseph Porter III did not immediately return a phone message seeking comment.
No criminal charges were filed over the fight, but Brown may face criminal penalties after he was arrested last month in Washington, D.C. for allegedly punching a man outside a hotel.
Brown remains on probation for his 2009 attack on then-girlfriend Rihanna and is due for a hearing in Los Angeles on Nov. 20, during which the new case may be addressed. Brown spent a day and a half in custody and faces a misdemeanor battery charge over the incident.
The R&B singer entered rehab for anger management issues on Oct. 29.
RAMALLAH, West Bank (AP) — Yasser Arafat's mysterious 2004 death turned into a whodunit Thursday after Swiss scientists who examined his remains said the Palestinian leader was probably poisoned with radioactive polonium.
Yet hard proof remains elusive, and nine years on, tracking down anyone who might have slipped minuscule amounts of the lethal substance into Arafat's food or drink could be difficult.
A new investigation could also prove embarrassing — and not just for Israel, which the Palestinians have long accused of poisoning their leader and which has denied any role.
The Palestinians themselves could come under renewed scrutiny, since Arafat was holed up in his Israeli-besieged West Bank compound in the months before his death, surrounded by advisers, staff and bodyguards.
Arafat died at a French military hospital on Nov. 11, 2004, at age 75, a month after suddenly falling violently ill at his compound. At the time, French doctors said he died of a stroke and had a blood-clotting problem, but records were inconclusive about what caused that condition.
The Swiss scientists said that they found elevated traces of polonium-210 and lead in Arafat's remains that could not have occurred naturally, and that the timeframe of Arafat's illness and death was consistent with poisoning from ingesting polonium.
"Our results reasonably support the poisoning theory," Francois Bochud, director of Switzerland's Institute of Radiation Physics, which carried out the investigation, said at a news conference.
Bochud and Patrice Mangin, director of the Lausanne University Hospital's forensics center, said they tested and ruled out innocent explanations, such as accidental poisoning.
"I think we can eliminate this possibility because, as you can imagine, you cannot find polonium everywhere. It's a very rare toxic substance," Mangin told The Associated Press.
Palestinian officials, including Arafat's successor, Palestinian President Mahmoud Abbas, had no comment on the substance of the report but promised a continued investigation.
The findings are certain to revive Palestinian allegations against Israel, a nuclear power. Polonium can be a byproduct of the chemical processing of uranium, but usually is made artificially in a nuclear reactor or a particle accelerator.
Arafat's widow, Suha, called on the Palestinian leadership to seek justice for her husband, saying, "It's clear this is a crime."
Speaking by phone from the Qatari capital Doha, she did not mention Israel but argued that only countries with nuclear capabilities have access to polonium.
In another interview later Thursday, she described her husband's death as a "political assassination" and "the crime of the century" and called the new testing conclusive for poisoning. She said she couldn't predict who was behind the death, but she added, "Whoever did this crime is a coward."
Israel has repeatedly denied a role in Arafat's death and did so again Thursday. Paul Hirschson, a Foreign Ministry official, dismissed the claim as "hogwash."
"We couldn't be bothered to" kill him, Hirschson said. "If anyone remembers the political reality at the time, Arafat was completely isolated. His own people were barely speaking to him. There's no logical reason for Israel to have wanted to do something like this."
In his final years, Arafat was being accused by Israel and the U.S. of condoning and even encouraging Palestinian attacks against Israelis instead of working for a peace deal. In late 2004, Israeli tanks no longer surrounded his compound, but Arafat was afraid to leave for fear of not being allowed to return.
Shortly after his death, the Palestinians launched their own investigation, questioning dozens of people in Arafat's compound, including staff, bodyguards and officials, but no suspects emerged.
Security around Arafat was easily breached toward the end of his life. Aides have described him as impulsive, unable to resist tasting gifts of chocolate or trying out medicines brought by visitors from abroad.
The investigation was dormant until the satellite TV station Al-Jazeera persuaded Arafat's widow last year to hand over a bag with her husband's underwear, headscarves and other belongings. After finding traces of polonium in biological stains on the clothing, investigators dug up his grave in his Ramallah compound earlier this year to take bone and soil samples.
Investigators noted Thursday that they could not account for the chain of custody of the items that were in the bag, leaving open the possibility of tampering.
However, the latest findings are largely based on Arafat's remains and burial soil, and in this case, tampering appears highly improbable, Bochud said.
"I think this can really be ruled out because it was really difficult to access the body," he said. "When we opened the tomb, we were all together."
Polonium-210 is the same substance that killed KGB agent-turned-Kremlin critic Alexander Litvinenko in London in 2006.
"It's quite difficult to understand why (Arafat) might have had any polonium, if he was just in his headquarters in Ramallah," said Alastair Hay, a professor of environmental toxicology at the University of Leeds who was not involved in the investigation.
"He wasn't somebody who was moving in and out of atomic energy plants or dealing with radioactive isotopes."
___
John Heilprin reported from Lausanne, Switzerland. Associated Press writers Daniel Estrin in Jerusalem and Lori Hinnant in Paris and AP Medical Writer Maria Cheng in London contributed to this report.
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