She has no problem sharing her thoughts on Twitter, but Kylie Jenner may have stepped over the line with her recent comments about a specific mental illness.
On Wednesday (November 6), the "Keeping Up with the Kardashians" star posted an old pic donning her darker locks and added the caption, "I miss my black hair I'm so bipolar :(."
Unfortunately, the politically incorrect comment didn't sit too well with other Twitter users. One observer fired back with, "Kylie Jenner just tweeted 'I miss my black I'm so Bipolar :(' . No, you're not 'so Bipolar', you're indecisive... and a moron."
Another wrote, "That was 100% the dumbest and most ignorant use of the word bipolar."
Miss Jenner has yet to respond to the negative tweets at this time.
Unique change in protein structure guides production of RNA from DNA
PUBLIC RELEASE DATE:
7-Nov-2013
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Contact: Anne Holden anne.holden@gladstone.ucsf.edu 415-734-2534 Gladstone Institutes
Gladstone-led study sheds light on critical molecular process
SAN FRANCISCO, CANovember 7, 2013One of biology's most fundamental processes is something called transcription. It is just one step of many required to build proteinsand without it life would not exist. However, many aspects of transcription remain shrouded in mystery. But now, scientists at the Gladstone Institutes are shedding light on key aspects of transcription, and in so doing are coming even closer to understanding the importance of this process in the growth and development of cellsas well as what happens when this process goes awry.
In the latest issue of Molecular Cell, researchers in the laboratory of Gladstone Investigator Melanie Ott, MD, PhD, describe the intriguing behavior of a protein called RNA polymerase II (RNAPII). The RNAPII protein is an enzyme, a catalyst that guides the transcription process by copying DNA into RNA, which forms a disposable blueprint for making proteins. Scientists have long known that RNAPII appears to stall or "pause" at specific genes early in transcription. But they were not sure as why.
"This so-called 'polymerase pausing' occurs when RNAPII literally stops soon after beginning transcription for a short period before starting up again," explained Dr. Ott, who is also a professor of medicine at the University of California, San Francisco, with which Gladstone is affiliated. "All we knew was that this behavior was important for the precise transcription of DNA into RNA, so we set out to understand how, when andmost importantlywhy."
The research team focused their efforts on a segment of RNAPII called the C-terminal domain, or CTD. This section is most intimately involved with transcription regulation. Previous research had found that CTD's chemical structure is modified before and during transcription. However, the combinations of modifications as well as precisely how they influence or control transcription remained unclear. So in laboratory experiments on cells extracted from mammals, the researchers took a closer look.
The first breakthrough came when the research team identified a new type of modification, known as acetylation, which regulated transcription.
"Our next breakthrough occurred when we pinpointed the precise locations on the CTD where acetylation occurredand realized it was unique to higher eukaryotes," explained Sebastian Schrder, PhD, the paper's first author. "We then wanted to see how this mammalian-specific acetylation fit into the realm of polymerase pausing."
Now that the team knew where the CTD became acetylated, their next goal was to find out when. Clues to the timing of acetylation came in experiments where they mutated RNAPII so that CDT was unable to become acetylated. In these cases, the length of polymerase pausing dropped, and the necessary steps for the completion of transcription failed to occur. Additional experiments revealed the elusive timeline of acetylation and transcription.
"RNAPII binds to DNA to prepare for transcription. Shortly after that we see polymerase pausingat which point the CTD becomes highly acetylated," continued Dr. Shrder. "Soon after the pause, CTD is then deacetylatedthe original modification is reversedand transcription continues without a hitch."
Polymerase pausing is not unique to mammalsin fact it was characterized in HIV, the virus that causes AIDS, many years agobut the fact that the CTD becomes acetylated just before or during the time when transcription is paused appears to be unique. Drs. Ott and Schrder argue that CTD acetylation is a stabilizer, preparing RNAPII for efficient completion of transcription and slowing down the process to make sure everything is functioning correctlynot unlike the final 'systems check' a pilot must perform before takeoff.
These findings offer important insight into the relationship between acetylation and transcription. And given the importance of transcription in the growth and maturation of cells in general, the team's result stands to inform scientists about a variety of cellular processes. These include, for example, the mechanisms behind stem-cell development and what happens when normal cellular growth spirals out of control, such as in cancer.
"However, there is still much we don't know about acetylation as it relates to transcription," said Dr. Ott. "For example, if CTD acetylation is important for stabilizing transcriptional pausing, why do we also see CTD acetylation at non-paused genes, although at different locations? Further, we believe there may be other steps in the transcription cycle that depend upon acetylation. Our most immediate goal is to find them. By doing so, we hope to deepen our understanding of one of nature's most elegant biological processes."
###
Dr. Schrder performed this research at Gladstone while completing his PhD at the University of Heidelberg, Germany. Eva Herker, PhD, Sean Thomas, Phd, Katrin Kaehlcke, Sungyoo Cho, Katherine Pollard, PhD, John Capra, PhD and Benoit Bruneau, PhD, also participated in this research at Gladstone, which was supported by the National Institutes of Health, the National Institute of Environmental Health Sciences, the Boehringer Ingelheim Fonds, the Human Frontiers Science Program and an E.G.G. fellowship.
About the Gladstone Institutes
Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and innovation to prevent, treat and cure cardiovascular, viral and neurological diseases. Gladstone is affiliated with the University of California, San Francisco.
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Unique change in protein structure guides production of RNA from DNA
PUBLIC RELEASE DATE:
7-Nov-2013
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Contact: Anne Holden anne.holden@gladstone.ucsf.edu 415-734-2534 Gladstone Institutes
Gladstone-led study sheds light on critical molecular process
SAN FRANCISCO, CANovember 7, 2013One of biology's most fundamental processes is something called transcription. It is just one step of many required to build proteinsand without it life would not exist. However, many aspects of transcription remain shrouded in mystery. But now, scientists at the Gladstone Institutes are shedding light on key aspects of transcription, and in so doing are coming even closer to understanding the importance of this process in the growth and development of cellsas well as what happens when this process goes awry.
In the latest issue of Molecular Cell, researchers in the laboratory of Gladstone Investigator Melanie Ott, MD, PhD, describe the intriguing behavior of a protein called RNA polymerase II (RNAPII). The RNAPII protein is an enzyme, a catalyst that guides the transcription process by copying DNA into RNA, which forms a disposable blueprint for making proteins. Scientists have long known that RNAPII appears to stall or "pause" at specific genes early in transcription. But they were not sure as why.
"This so-called 'polymerase pausing' occurs when RNAPII literally stops soon after beginning transcription for a short period before starting up again," explained Dr. Ott, who is also a professor of medicine at the University of California, San Francisco, with which Gladstone is affiliated. "All we knew was that this behavior was important for the precise transcription of DNA into RNA, so we set out to understand how, when andmost importantlywhy."
The research team focused their efforts on a segment of RNAPII called the C-terminal domain, or CTD. This section is most intimately involved with transcription regulation. Previous research had found that CTD's chemical structure is modified before and during transcription. However, the combinations of modifications as well as precisely how they influence or control transcription remained unclear. So in laboratory experiments on cells extracted from mammals, the researchers took a closer look.
The first breakthrough came when the research team identified a new type of modification, known as acetylation, which regulated transcription.
"Our next breakthrough occurred when we pinpointed the precise locations on the CTD where acetylation occurredand realized it was unique to higher eukaryotes," explained Sebastian Schrder, PhD, the paper's first author. "We then wanted to see how this mammalian-specific acetylation fit into the realm of polymerase pausing."
Now that the team knew where the CTD became acetylated, their next goal was to find out when. Clues to the timing of acetylation came in experiments where they mutated RNAPII so that CDT was unable to become acetylated. In these cases, the length of polymerase pausing dropped, and the necessary steps for the completion of transcription failed to occur. Additional experiments revealed the elusive timeline of acetylation and transcription.
"RNAPII binds to DNA to prepare for transcription. Shortly after that we see polymerase pausingat which point the CTD becomes highly acetylated," continued Dr. Shrder. "Soon after the pause, CTD is then deacetylatedthe original modification is reversedand transcription continues without a hitch."
Polymerase pausing is not unique to mammalsin fact it was characterized in HIV, the virus that causes AIDS, many years agobut the fact that the CTD becomes acetylated just before or during the time when transcription is paused appears to be unique. Drs. Ott and Schrder argue that CTD acetylation is a stabilizer, preparing RNAPII for efficient completion of transcription and slowing down the process to make sure everything is functioning correctlynot unlike the final 'systems check' a pilot must perform before takeoff.
These findings offer important insight into the relationship between acetylation and transcription. And given the importance of transcription in the growth and maturation of cells in general, the team's result stands to inform scientists about a variety of cellular processes. These include, for example, the mechanisms behind stem-cell development and what happens when normal cellular growth spirals out of control, such as in cancer.
"However, there is still much we don't know about acetylation as it relates to transcription," said Dr. Ott. "For example, if CTD acetylation is important for stabilizing transcriptional pausing, why do we also see CTD acetylation at non-paused genes, although at different locations? Further, we believe there may be other steps in the transcription cycle that depend upon acetylation. Our most immediate goal is to find them. By doing so, we hope to deepen our understanding of one of nature's most elegant biological processes."
###
Dr. Schrder performed this research at Gladstone while completing his PhD at the University of Heidelberg, Germany. Eva Herker, PhD, Sean Thomas, Phd, Katrin Kaehlcke, Sungyoo Cho, Katherine Pollard, PhD, John Capra, PhD and Benoit Bruneau, PhD, also participated in this research at Gladstone, which was supported by the National Institutes of Health, the National Institute of Environmental Health Sciences, the Boehringer Ingelheim Fonds, the Human Frontiers Science Program and an E.G.G. fellowship.
About the Gladstone Institutes
Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and innovation to prevent, treat and cure cardiovascular, viral and neurological diseases. Gladstone is affiliated with the University of California, San Francisco.
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Roughly three-quarters of South Africa's Jewish population are descendants of Lithuanian immigrants. Of these peasants, townspeople, tradesmen, shopkeepers and intellectuals who fled centuries of persecution and embarked on a passage to Africa, many dreamed of a new land and the promise of new beginnings. Kenneth Bonert's ancestors were part of this diaspora. In his debut novel, written in language as dense and varied as the South African landscape he describes, Bonert delivers a taut, visceral account of a young Jewish boy's African life.
These are the years of the Great Depression, the period between the wars. The protagonist, Isaac Helger, arrives in South Africa with his mother and younger sister, reuniting with a father who had made the journey years before. Their reunion marks the beginning of family life, but the fate of the relatives left behind, and the impact of a separation they all pray will be temporary, will reach far into their future. Most affected by this separation is Gitelle, Isaac's mother — a woman who has more reason than most to leave the past behind.
The voices of Isaac and his mother especially are brought to life through Bonert's skilful prose — a beguiling mixture of delicate, poetic sensitivity and rugged, at times despondent, masculinity. Dialogue is believably rendered in language that is visceral and heavily inflected with the Yiddish, Afrikaans and South African accent that make up the particular voice of the Helger family's migration. As their ship lands in Cape Town, Gitelle's first experience of this new country is almost overwhelming, so vivid is the description:
Colors burned the air, blood flowers, thorny eruptions of vermilion, limeyellow smears on the rocks like veins of fresh paint ... she saw human beings burned the color of coal or dark-brewed tea or cured leather; she smelled their alien sweat and their tangy cooking, heard the mad bibbering of their manifold tongues. A strange music that made her heart sing in fear of this shattering place.
Gitelle does not linger long on this fear, for we soon learn that what she has survived is so terrible that there is little left that she cannot endure. When we meet Gitelle, her face is covered with a veil, and while the source and nature of the deformity she is hiding are not clear in the early pages of the book, her determination is. Very quickly she sets to building a home for her family. In one memorable scene she clears out the "bladerfools" and "parasites" — the friends she feels are sapping her watchmaker husband's time and energy.
Born in South Africa, grandson to Lithuanian immigrants, Kenneth Bonert has contributed stories to the magazines Grain and Fiddlehead. His novella, "Peacekeepers, 1995," appeared in McSweeney's.
Richard Dubois/Courtesy of Houghton Mifflin Harcourt
Born in South Africa, grandson to Lithuanian immigrants, Kenneth Bonert has contributed stories to the magazines Grain and Fiddlehead. His novella, "Peacekeepers, 1995," appeared in McSweeney's.
Richard Dubois/Courtesy of Houghton Mifflin Harcourt
Though Gitelle remains a necessary and constant focus of the narrative, it is Isaac's life that the story follows. He is not always a sympathetic character — rough-hewn, bull-headed and often violent. As Isaac grows from a boyhood filled with fights, truancy and early disregard for the rules of this new place, his mother urges him constantly to a better future. Theirs is a potentially destructive relationship of tenderness and mutual dependence.
Together they dream of moving to a house in a better suburb — one that will have room for the sisters she still hopes, despite the passage of time and anti-Jewish immigration laws, to rescue from Lithuania. Spurred by her blind faith, Isaac leaves school with no qualifications and bets on several money-making schemes (some legal, many not). Eventually, in a show of youthful independence, he defies his mother's wishes and settles in as an apprentice in an auto-repair shop.
Throughout all this, Bonert does not shirk from the fetid truth upon which the opportunities of immigrants such as the Helger's are built. The Lion Seeker deftly handles the questions of compliance and collusion that mark this period in history. Fleeing hardship in Europe, Isaac and his family now claim a new status; no longer at the bottom of the pile. Life may be difficult and they may still face prejudice, but at least they are not black. Gitelle, with a determined sense of self-preservation, puts it to Isaac plainly: "We are Jews but we are Whites here. If People see you with Coloreds and hear you talk like that ... then they will think maybe we have coffee in our blood also ... That's dangerous. Do you understand me?"
Thankfully, Bonert is too thoughtful a writer to allow Isaac an epiphany and the resulting bleeding heart. Instead, Isaac is only too willing to claim the superior status that his white skin gives him. His prejudice is not a thought-out thing, although no less diminishing for that lack of intent. Bonert makes this point with carefully considered characterization and scenes that are unforgiving in their judgement. Isaac's easy acceptance of the privileges his color allows make him as complicit as all around him.
Isaac falls in love with the lithesome Yvonne, the spoiled only child of a wealthy English-speaking couple. She's of a class that is voluble in their liberal affectations. No matter that the very fabric of their lives depends on the inequalities of this pre-apartheid era. Yvonne's criticism that Isaac is willfully ignorant of the "Native Question" causes tension, causing Isaac is at last to question his easy acceptance of the status quo. However, his own experience of working with blacks — and forming friendships, of a kind, with them — far outstrips the tennis-club rhetoric of Yvonne and her kind.
All through this growing up, and the richly-drawn glimpses we have of South Africa and the wider world, there is an assured confidence to Bonert's narration, with an undercurrent of menace that is skilfully and affectingly wrought. Isaac settles uneasily into manhood with the possibility of war in Europe looming ever larger, as well as the quotidian brutality of the color-bar and the constant reminders of the precarious nature of life as a Jew. Gitelle still mourns the family she has left behind, never giving up her determination to bring them to safety. When, at great personal cost to herself and the possible exposure of a closely held secret, it seems she has found a way, Isaac makes a catastrophic decision for which one does not imagine there can be redemption.
This is a first novel, and so it is easy to forgive the occasional tremors in plotting that felt, towards the end of the book, too close to melodrama, and the inclusion of an epilogue that is out of voice and feels tacked on for poignant effect. The Lion Seeker is a captivating story, offering at times page-turning thrills and at others a painful meditation on destiny and volition. All too often debut novels stay too close to a writer's own life; it is a great gift to be able to mine family history and flex the imagination to create something that exudes such urgency and brilliance as this memorable book.
Amid the clamor of "bring your own device" (BYOD), a question lurks in the background: "What happens to technical service and support?" Concerns for the tech support function encompass the extremes, from agents being overwhelmed with calls, to their becoming inhabitants of a help desk ghost town.
On the one hand, it’s easy to imagine a flood of calls as employees attempt to access wireless networks or synch their e-mail, especially in companies that permit the use of any device type. At the same time, as more people own smartphones, they are increasingly accustomed to resolving issues independently, through online forums, communities and other means of self-support.
By 2016, says Gartner analyst Jarod Greene, help desks will see a 25% to 30% drop in user-initiated call volume, as BYOD drives a companion trend of BYOS, or “bring your own support.”
Iranian Foreign Minister Mohammed Javad Zarif waits for the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
Iranian Foreign Minister Mohammed Javad Zarif waits for the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
U.S. Under Secretary of State for Political Affairs Wendy Sherman arrives prior to the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
A general view shows participants before the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
EU High Representative for Foreign Affairs Catherine Ashton, left, speaks with Iranian Foreign Minister Mohammed Javad Zarif, right, during a photo opportunity prior the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
EU High Representative for Foreign Affairs Catherine Ashton, right, walks next to Iranian Foreign Minister Mohammed Javad Zarif, left, during a photo opportunity prior to the start of two days of closed-door nuclear talks at the United Nations offices in Geneva Switzerland, Thursday, Nov. 7, 2013. Six world powers are dangling the prospect of easing some sanctions against Iran if Tehran agrees to curb work that could be used to make nuclear weapons. Talks resume Thursday between Iran and the six _ The United States, Russia, China, Britain, France and Germany. (AP Photo/Keystone, Martial Trezzini)
GENEVA (AP) — Iran's chief nuclear negotiator signaled progress at talks with six world powers Thursday on a deal to cap some of his country's atomic programs in exchange for limited relief from sanctions stifling Iran's economy, saying the six had accepted Tehran's proposals on how to proceed.
U.S. officials said Secretary of State John Kerry will fly to Geneva on Friday to participate in the negotiations — a last-minute decision that suggests a deal could be imminent.
A senior State Department official traveling with Kerry in Amman, Jordan, said the secretary would come to Geneva "to help narrow differences in negotiations." The official spoke on condition of anonymity because he was not authorized to release information about the Geneva visit.
Even if an agreement is reached, it would only be the start of a long process to reduce Iran's potential nuclear threat, with no guarantee of ultimate success.
Still, a limited accord would mark a breakthrough after nearly a decade of mostly inconclusive talks focused on limiting, if not eliminating, Iranian atomic programs that could be turned from producing energy into making weapons.
Tehran's chief nuclear negotiator, Abbas Araghchi, told Iranian state TV that the six — the United States, Russia, China, Britain, France and Germany — "clearly said that they accept the proposed framework by Iran." He later told CNN that he thinks negotiators at the table are now "ready to start drafting" an accord that outlines specific steps to be taken.
Though Araghchi described the negotiations as "very difficult," he told Iranian state TV that he expected agreement on details by Friday, the last scheduled round of the current talks.
The upbeat comments suggested that negotiators in Geneva were moving from broad discussions over a nuclear deal to details meant to limit Tehran's ability to make atomic weapons. In return, Iran would start getting relief from sanctions that have hit its economy hard.
U.S. officials said Kerry will travel to the Geneva talks after a brief stop in Israel, where he will hold a third meeting with Israeli Prime Minister Benjamin Netanyahu, who has spoken out against any limited deal that would allow the Iranians sanctions relief.
In Geneva, Kerry is expected to meet Friday with the European Union's top diplomat, Catherine Ashton, and Iranian Foreign Minister Mohammad Javad Zarif, the officials said. They spoke on condition of anonymity because they were not authorized to comment on the schedule.
The talks are primarily focused on the size and output of Iran's enrichment program, which can create both reactor fuel and weapons-grade material suitable for a nuclear bomb. Iran insists it is pursuing only nuclear energy, medical treatments and research, but the United States and its allies fear that Iran could turn this material into the fissile core of nuclear warheads.
International negotiators representing the six powers declined to comment on Araghchi's statement. Bur White House spokesman Jay Carney elaborated on what the U.S. calls a "first step" of a strategy meant to ultimately contain Iran's ability to use its nuclear program to make weapons.
An initial agreement would "address Iran's most advanced nuclear activities; increase transparency so Iran will not be able to use the cover of talks to advance its program; and create time and space as we negotiate a comprehensive agreement," Carney told reporters in Washington.
The six would consider "limited, targeted and reversible relief that does not affect our core sanctions," he said, alluding to penalties crippling Tehran's oil exports. If Iran reneges, said Carney, "the temporary, modest relief would be terminated, and we would be in a position to ratchet up the pressure even further by adding new sanctions."
He described any temporary, initial relief of sanctions as likely "more financial rather than technical." Diplomats have previously said initial sanction rollbacks could free Iranian funds in overseas accounts and allow trade in gold and petrochemicals.
Warily watching from the sidelines, Israel warned against a partial agreement that foresees lifting sanctions now instead of waiting for a rigorous final accord that eliminates any possibility of Iran making nuclear weapons.
At a meeting with U.S. legislators in Jerusalem, Netanyahu spoke of "the deal of the century for Iran." While divulging no details, he said the proposed first step at Geneva "will relieve all the (sanctions) pressure inside Iran."
The last round of talks three weeks ago reached agreement on a framework of possible discussion points, and the two sides kicked off Thursday's round focused on getting to that first step.
Thursday's meeting ended about an hour after it began, followed by bilateral meetings, including one between the U.S and Iranian delegations. EU spokesman Michael Mann said the talks were "making progress."
Before the morning round, Zarif, the Iranian foreign minister, met with the EU's Ashton, who is convening the meeting. Asked afterward about the chances of agreement on initial steps this week, Zarif told reporters: "If everyone tries their best, we may have one."
After nearly a decade of deadlock, Iran seems more amenable to making concessions to the six countries. Iran's new president, Hassan Rouhani, has indicated he could cut back on the nuclear program in exchange for an easing of sanctions.
Despite the seemingly calmer political backdrop, issues remain.
Iranian hardliners want a meaningful — and quick — reduction of the sanctions in exchange for any concessions, while some U.S. lawmakers want significant rollbacks in Iran's nuclear activities in exchange for any loosening of actions.
_____
Associated Press Diplomatic Writer Matthew Lee in Amman, Jordan, contributed to this report. AP writers Josef Federman in Jerusalem, Jim Kuhnhenn in Washington and Nasser Karimi in Tehran also contributed.
Feeling perky post-split? Liberty Ross proudly flaunted her body on the red carpet of the MOCA Awards in Beverly Hills on Wednesday, Nov. 6. The 35-year-old estranged wife of Rupert Sanders went braless in a see-through black dress that exposed her nipples.
Ross appeared to be in great spirits at the event, flashing a big smile to photographers while posing on the carpet. The model styled a short, sleeveless dress with a sheer black bodice and white-and-black printed skirt and black high-heels. The British mom of two also playfully posed in a pair of dark shades, which she later placed on the top of her head.
Ross recently opened up to Vanity Fair about life after her husband's public affair. The Snow White and the Huntsman director was caught cheating with the star of his movie, Kristen Stewart, on July 17, 2012.
"It was horrible," Ross told the December issue of the magazine. "It was really the worst, really the worst."
After filing for divorce from Sanders in January 2013, Ross, who is now dating music honcho Jimmy Iovine, said she's finally moving on. "I have no words to describe what we went through," she told Vanity Fair. "But I think, for me, something always has to completely die for there to be a rebirth. And, for me, I feel like I'm going through a rebirth."
Out for a quick trim in Beverly Hills, CA today (November 7), "Mad Men" momma January Jones took her son Xander to get a haircut.
The 35-year-old dressed casually, wearing shades, and sporting a white button down and blue jeans. Little Xander rode along on his mommy's hip, wearing a gray cap, blue polo and jeans.
In related news, AMC announced that "Mad Men's" seventh and final season will be 14 episodes long and be split into two hlaves, with the first seven episodes of the extended season airing in Spring 2014 and the second seven episodes airing in Spring 2015.
Fans of the show can now purchase the series' sixth season on DVD, which just hit stores this week. Enjoy!
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